Direction of work – study of the morphogenesis of general pathological, compensatory-adaptive and regenerative processes in organs and tissues; modeling of socially significant chronic diseases. Research methods - morphological, functional, immunohistochemical.

Graduated in 1977 G. Novosibirsk State University, in 1994 G. defended her thesis on the topic "Ultrastructural and cytochemical analysis of the rat myocardium under extreme temperature effects", in 1999 G. – doctoral dissertation on the topic “Ultrastructural foundations of adaptive myocardial reorganization under the action of extreme environmental factors (contrasting temperatures and hypogeomagnetic environment)».

The main direction of scientific research is the study of the structural mechanisms of compensatory-adaptive reactions under the influence of extreme environmental factors and age-related features of regeneration and remodeling of the heart..

M.G. Klinnikova studied the general patterns of structural reorganization of the myocardium on the tissue, cellular and intracellular levels under the action of contrasting temperature effects and hypogeomagnetic environment on the body, and the main criteria for the morphofunctional state of the myocardium under these conditions are identified. Installed, that changes in tissue reorganization of the myocardium to a greater extent reflect the nonspecific response of the heart muscle to the development of stress and are an integral part of the general adaptation syndrome. When studying the age-related features of myocardial reorganization, it was shown, that remodeling of the heart in late ontogenesis can occur without a significant decrease in the total number of cardiomyocytes, while with cardiotoxic effects, a key factor, determining dilated remodeling of the heart, is a pronounced decrease in the total number of cardiomyocytes as a result of their death by apoptosis. The molecular-biological and structural reorganization of the myocardium of Wistar rats was studied in the dynamics of the experiment on modeling anthracycline cardiomyopathy and the administration of betulonic acid amide and atorvastatin as cytoprotectors.. Installed, that cytoprotective reactions are induced in the myocardium, initially on the intracellular, then at the cellular level.

Author over 70 scientific papers. Led by reserved 2 PhD dissertations.

M.G. Klinnikova - Scientific Secretary of the Council for the Defense of Doctoral and Candidate's Dissertations 24.1.242.03 in FGBNU "FITS FTM" (specialty - "cell biology").

Major Publications:

1. Tursunovaa N.V., Klinnikovaa M.G., Babenko O.A., Lushnikova E.L. Molecular Mechanisms of the Cardiotoxic Action of Anthracycline Antibiotics and Statin-Induced Cytoprotective Reactions of Cardiomyocytes // Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry. – 2021. – Vol. 15, No. 2. – P. 89–104.DOI: 10.1134/S1990750821020116
2. Maiborodin I., Shevela A., Toder M., Marchukov S., Tursunova N., Klinnikova M., Maiborodina V., Lushnikova E., Shevela A. Multipotent Stromal Cell Extracellular Vesicle Distribution in Distant Organs after Introduction into a Bone Tissue Defect of a Limb // Life. – 2021. – Vol.11, 306. https://doi.org/10.3390/life11040306
3. Maiborodin I., Lushnikova E., Klinnikova M., Klochkova S. Some Special Aspects of Liver Repair after Resection and Administration of Multipotent Stromal Cells in Ex-periment // Life. –2021. – Vol.11, 66.https://doi.org/10.3390/life11010066
4. Maiborodin I.V., Agzaev M.K., Maiborodina V.I., Klinnikova M.G.. Differences in morphological responses of regional lymph nodes in young and adult rats to tissue injury in the region of lymph collection // Modern problems of science and education. – 2020. – № 5.; URL: http://www.science-education.ru/ru/article/view?id=30166 (date of the application: 10.10.2020). DOI 10.17513/spno.30166
5. Tursunova N.V., Klinnikova M.G., Babenko O.A., Lushnikova E.L. Molecular mechanisms of correction of cardiotoxic effects of anthracyclines by cardioprotectors // Modern problems of science and education. – 2020. – № 4; URL: http://www.science-ducation.ru/article/view?id=30035
6. Klinnikova M.G., Tursunova N.V., Klochkova S.V., Lushnikova E.L. Dynamics of the number of cardiomyocytes in the heart under isolated and combined exposure to doxorubicin and atorvastatin // Modern problems of science and education. – 2020. – № 1; DOI 10.17513/spno.29427
7. Klinnikova M.G., Koldysheva E.V., Tursunova N.V., Semenov D.E., Lushnikova E.L. Features of Myocardial Remodeling and Changes in the Blood Lipid Spectrum in Experimental Doxorubicin-Induced Cardiomyopathy and Atorvastatin Administration // Bulletin of Experimental Biology and Medicine. – 2020. – Vol. 170, No. 1 (November). – P. 24 – 29. DOI 10.1007/s10517-020-04997-1
8. Lushnikova E.L., Molodykh O.P., Nikityuk D.B., Semenov D.E., Klinnikova M.G. Structural Analysis of the Myocardium in Experimental Anthracycline-Induced Cardiomyopathy Combined with Adrenergic Stimulation // Bulletin of Experimental Biology and Medicine. – 2019. – Vol. 166, No. 5 (March). – P. 689 – 694. DOI 10.1007/s10517-019-04419-x http://link.springer.com/article/10.1007/s10517-019-04419-x
9. Tursunova N.V., Klinnikova M.G., Tornuev Yu.V., Lushnikova E.L. Plant polyprenols as a promising class of compounds, stimulating regenerative processes // Modern problems of science and education. – 2019. – № 4. DOI 10.17513/spno.28977
10. Lushnikova E.L., Mzhelskaya M.M., Koldysheva E.V., Klinnikova M.G.. Immunohistochemical evaluation of vasoendothelial growth factor receptor-2 expression (VEGFR2) in rat cardiomyocytes under the action of doxorubicin and betulonic acid amide // Siberian scientific medical journal. – 2018. – № 6. – S. 5 – 12. DOI: 10.15372/SSMJ20180601
11. Lushnikova E.L., Klinnikova M.G., Klochkova S.V., Molodykh O.P.. Ultrastructural characteristics of cardiomyocyte damage under combined doxorubicin and adrenaline effects // Modern problems of science and education. – 2018. – № 6; URL: http://www.science-education.ru/article/view?id=28235
12. Klinnikova M.G., Koldysheva E.V., Korolenko T.A., Lushnikova E.L. Expression of Flk-1 and cyclin D2 mRNA in myocardium with doxorubicin-induced cardiomyopathy // Abstracts. International Academy of Cardiology. Annual Scientific Sessions 2018. 23rd World Congress on Heart Disease. Boston, MA, USA, July 27-29, 2018 // Cardiology. – 2018. – Vol. 140, Suppl. 1. – P. 403. http://doi.org/10.1159/000491714
13. Lushnikova E.L., Semenov D.E., Nikityuk D.B., Koldysheva E.V., Klinnikova M.G. Intracellular reorganization of cardiomyocytes in dyslipidemic cardiomyopathies // Bulletin of Experimental Biology and Medicine. 2018. Vol. 164 (4). P. 508–513. DOI 10.1007/s10517-018-4022-0
14. Koldysheva E.V., Klinnikova M.G., Nikityuk D.B., Ivleva E.K., Listvyagova N.A., Lushnikova E.L. Role of matrix metalloproteinase-2 in the development of cyclophosphamide-induced cardiomyopathy // Bull. Exp Biol Med. – 2018 (February). – Vol. 164 (4). – P. 483 – 487. DOI 10.1007/s10517-018-4017-x
15. Mzhelskaya M.M., Klinnikova M.G., Koldysheva E.V., Lushnikova E.L. Expression of Flk-1 and cyclin D2 mRNA in the myocardium of rats with doxorubicin-induced cardiomyopathy and after treatment with betulonic acid amide // Bull. Exper. Biol. With. – 2017. – Vol. 163, № 6. – P. 809-813. DOI 10.1007/s10517-017-3909-5
16. Klinnikova M.G., Bakarev M.A., Nikityuk D.B., Lushnikova E.L. Immunohistochemical Analysis of Vasoendothelial Growth Factor Receptor-2 Expression (KDR/Flk-1) with myocardial infarction // Bull. expert. biol. – 2017. - T. 163, № 4. – S. 503 – 508.
17. Lushnikova E.L., Nikityuk D.B., Klinnikova M.G., Koldysheva E.V., Mzhelskaya M.M.. Expression of matrix metalloproteinase-2 in the myocardium in the modeling of anthracycline cardiomyopathy // Morphology. – 2016. - T. 150, № 6. – S. 29 – 33.
18. Lushnikova E.L., Klinnikova M.G., Nikityuk D.B., Koldysheva E.V., Yuzhik E.I., Mzhelskaya M.M.. Structural basis of myocardial remodeling under the action of cyclophosphamide and K+ corrector, Mg2+ ion exchange in cardiomyocytes // Modern problems of science and education. – 2016. – № 5; URL: http: //www.science-education.ru/ru/article/view?id=25208
19. Klinnikova M.G., Lushnikova E.L., Koldysheva E.V., Tolstikova T.G., Sorokina I.V., Yuzhik E.I., Mzhelskaya M. M. Cardiotoxic and Dyslipidemic Effects of Doxorubicin and Betulinic Acid Amide // Bulletin of Experimental Biology and Medicine. – 2016. – Vol. 162, No. 2. DOI 10.1007/s10517-016-3594-9
20. Nepomnyashchikh L.M., Lushnikova E.L., Bakarev M.A., Nikityuk D.B., Yuzhik E.I., Mzhelskaya M.M., Nepomnyashchikh R.D., Klinnikova M.G., Karpova A.A. Immunohistochemical analysis of MMP-2 expression in the myocardium during the postinfarction period // Bulletin of Experimental Biology and Medicine. – 2015. – Vol.159, № 4. – P.504-510.
21. Yuzhik E.I., Lushnikova E.L., Klinnikova M.G., Pichigin V.I., Nepomnyashchikh L.M.. Expression of ryanodine receptor mRNA and sarcoplasmic Ca2+-ATPase mRNA in the myocardium and intracellular reorganization of cardiomyocytes in dyslipidemia and verapamil administration // Cellular technologies in biology and medicine. – 2014. – № 4. – S. 229 – 237.
22. Lushnikova E.L., Nepomnyashchikh L.M., Klinnikova M.G., Molodykh O.P., Yuzhik E.I., Nepomnyashchikh R.D., Pichigin V. I. Proliferative Activity of Cadriomyocytes in Chronic Hypercholesterolemia // Cell Technologies in Biology and Medicine, No. 4, February, 2014, p. 578.
23. Nepomnyashchikh L.M., Lushnikova E.L., Klinnikova M.G., Molodykh O.P.. The effect of drugs with antitumor activity - doxorubicin and cyclophosphamide - on the structural reorganization of the rat myocardium and the number of cardiomyocytes // Siberian journal of oncology. – 2011. – № 4. – S. 30 – 35.