Direction of research – study of the morphogenesis of general pathological, compensatory-adaptive and regenerative processes in organs and tissues in socially significant chronic diseases and in the context of the use of new treatment technologies; development of morphological diagnostic criteria, evaluation of the effectiveness of treatment, personalized selection of adequate correction methods. Research methods - morphological, functional, immunohistochemical.

Lapiy Galina Anatolyevna

Head of Laboratory - Chief Researcher. Doctor of Medical Sciences, professor

Graduated in 1984 G. Tomsk Medical Institute, in 1992 G. defended her thesis on the topic "Electronic microscopic and radioautographic examination of the gastric mucosa in peptic ulcer (according to gastrobiopsy)», in 1998 G. – doctoral dissertation on the topic “Pathomorphology of the stomach in chronic pathological processes of various genesis (chronic gastritis, peptic ulcer, gastropathy)», With 2006 G. - professor in the specialty "pathological anatomy".

The main direction of scientific research– complex pathomorphological analysis of chronic diseases of the digestive and genitourinary systems of various origins, study of the structural mechanisms of diseases of the artificial esophagus, development of criteria for morphological diagnosis and evaluation of the effectiveness of the treatment of these pathological conditions.

G.A. Lapiy established, that in modern environmental conditions chronic gastroenteric diseases (chronic gastritis, peptic ulcer, gastropathy of vibrational and mixed genesis) implemented on the basis of two structural response strategies: gastritis (chronic inflammatory process) and gastropathy (syndrome of regenerative plastic insufficiency). Morphological markers for the studied forms of chronic pathology have been developed, feature of which is a peculiar combination of damage reactions, compensation and regeneration. The induction of regenerative reactions by exposure to incoherent red light in duodenal ulcer has been shown.. Established morphogenetic features of gastrointestinopathy in psoriasis and opisthorchiasis, pancreatic injury, bronchial asthma.

New facts obtained about the spread of Helicobacter pylori in chronic gastroduodenal pathology of various origins, shows the ambiguity of the role of H. pylori infection in the formation and development of chronic pathological processes in the stomach. The results obtained form the basis for the development of a differential diagnostic algorithm, allowing with a high degree of accuracy to carry out pathomorphological diagnosis of chronic pathological processes in the gastroenteric zone with an assessment of the nature of damage and compensatory tissue reserves, which contributes to determining the prognosis of chronic diseases of the stomach.

The concept of the structural foundations of diseases of the artificial esophagus in the technologies of reconstructive and restorative interventions has been developed., performed for benign diseases of the esophagus. Morphological markers of adaptation reactions have been established, damage and compensation of gastric and colonic autografts in new conditions of functioning due to transposition and their performance of esophageal functions. A morphological substantiation of the advantage of choice for esophageal plasty in benign lesions of gastric tube grafts compared to colon grafts is presented..

New information has been obtained on the patterns of tissue remodeling in the correction of chronic urogynecological non-tumor diseases using innovative technologies. The possibility of tissue repair using a low-intensity erbium laser has been established, the clinical effect of which is based on the stimulation of regenerative reactions of fibrillar structures, microvessels, epithelium. As a result of complex experimental studies, the prospects for using a biodegradable polymer have been shown., obtained by electrospinning and consisting of 65% from polycaprolactone and 35% from polytrimethylene carbonate, as an alternative to polypropylene implants to eliminate ligamentous-muscular incompetence.

The obtained scientific knowledge is significant for fundamental science and can be applied in practical healthcare to improve pathomorphological diagnostics., treatment optimization, prevention and prognosis of this chronic pathology.

Author over 150 scientific papers, including 5 monographs. Led by reserved 9 PhD theses.

G.A. Lapiy - member of the council for the defense of doctoral and master's theses at FGBNU "FRC FTM" in the specialty "pathological anatomy".

For special achievements in pathomorphology, she was awarded a Diploma and the European Rudolf Virchow Medal. (Germany, 2007 Mr.).

Major Publications:

  1. Non-remembering G.I., Khardikova S.A., Aidagulova S.V., Lapiy G.A.. Psoriasis and opisthorchiasis: morphogenesis gastrointestinopathies. - M.: RAMS publishing house, 2003. – 175 With.
  2. Nepomnyashchikh D.L., Lapiy G.A., Aidagulova S.V., Bakarev M.A.. Biopsy in gastroenterology: Morphogenesis of general pathological processes - Moscow: Publishing House of the Russian Academy of Medical Sciences, 2010. – 368 With.
  3. Lapiy G.A., Nepomnyashchikh L.M., Chikinev Yu.V., Kutepov A.V.. Pathomorphology of the artificial esophagus with plastic gastric tube. - M.: RAMS publishing house, 2012. – 208 With.
  4. Chikinev Yu.V., Drobiazgin E.A., Lapiy G.A.. Plastic surgery of the esophagus in benign diseases. Immediate and long-term results. – Novosibirsk, 2012. – 288 With.
  5. Lapiy G.A., Nepomnyashchikh L.M., Chikinev Yu.V., Govorkov R.V. Pathomorphology of the artificial esophagus in colon plastic surgery. - M.: RAMS publishing house, 2013. – 240 With.
  6. Nepomnyashchikh L.M., Lapii G.A., Chikinev Yu.V., Sudovykh I.E., Tokmakov I.A. Cell reactions in gastric tube and colon transplants in stenoses of esophageal anastomosis // Bulletin of Experimental Biology and Medicine. – 2013. – Vol. 154, Issue 4, February. – P. 574 – 580.
  7. Lapii G.A., Nepomnyashchikh L.M., Kiptilov A.V., Neimark A.I. Morphofunctional analysis of the prostate exposed to chemical manufacture factors // Bulletin of experimental biology and medicine. – 2014. – Vol. 157, No 3, July. – P. 395-400.
  8. Nepomnyashchikh L.M., Lapiy G.A., Nikityuk D.B., Neimark A.I., Kiptilov A.V., Molodykh O.P.. Ultrastructural analysis of the prostate gland under the effect of factors of chemical industry // Bulletin of experimental biology and medicine. – 2015. – Vol. 158, No 6, April. – P. 827-834.
  9. Neimark A.I., Kiptilov A.V., Lapiy G.A.. Clinical and pathological features of chronic prostatitis in chemical production workers // Urology. – 2015. – № 6. – S. 68 – 73.
  10. Lapii G.A., Bakarev M.A., Nepomnyashchikh G.I., Kapustina V.I., Nepomnyashchikh D.L., Vinogradova E.V., Postnikova O.A. Structural characteristics of gastric cell populations in chronic gastritis and chronic hepatitis under conditions of Helicobacter pylori persistence // Bulletin of experimental biology and medicine. – February 2016. – Vol. 160, Issue 4. – P. 514 – 518.
  11. Lapii G.A., Yakovleva A. Yu., Neimark A.I. Structural reorganization of the vaginal mucosa in stress urinary incontinence under conditions of Er:YAG laser treatment // Bulletin of experimental biology and medicine. – February 2017. – Vol. 162, Issue 4. – P. 510 – 514.
  12. Lapii G.A., Yakovleva A. Yu., Neimark A.I., Lushnikova E.L. Study of proliferative activity of vaginal epithelium in women with stress urinary incontinence treated by Er:YAG laser // Bulletin of experimental biology and medicine. – June 2017. – Vol. 163, Issue 2. – P. 280 – 283.
  13. Neimark A.I., Yakovleva A.Yu., Lapiy G.A.. The results of the treatment of stress urinary incontinence in women with Er:YAG laser // Urology. – 2018. – № 2. – S. 20-25.
  14. Lapiy G.A., Yakovleva A.Yu., Abdullaev N.A., Neimark A.I.. Pathological analysis of the use of an erbium laser in the correction of stress urinary incontinence in women // Siberian scientific medical journal. – 2018. - T. 38, № 3. – S. 35-42.
  15. Lapii G.A., Molodykh O.P., Yakovlev A.V., Neimark A.I., Bakarev M.A. Ultrastructural analysis of urethral polyps against the background of urogenital infection // Bulletin of experimental biology and medicine. – October 2019. – Vol. 167, Issue 6. – P. 795 – 800.
  16. Pichigina A.K., Shelkovnikova N.V., Neimark A.I., Lapii G.A. Structural and functional bases of genitourinary syndrome of menopause // Bulletin of experimental biology and medicine. – November 2019. – Vol. 168, Issue 1. – P. 113 – 117. DOI 10.1007/s10517-019-04660-4
  17. Eisenach I.A., Bondarev O.I., You can V.G., Lapii G.A., Lushnikova E.L. Features of in vitro degradation and physical properties of a biopolymer and in vivo tissue reactions in comparison with polypropylene // Bulletin of experimental biology and medicine. – November, 2020. – Vol. 170, No. 1. – P. 88 – 92. doi: 10.1007/s10517-020-05010-5
  18. Lapii G.A., Molodykh O.P., Abdullaev N.A., Bakarev M.A. Features of remodeling of prostate stroma in chronic abacterial prostatitis // Bulletin of experimental biology and medicine. – January, 2021. – Vol. 170, No. 3. – P. 389 – 394. doi: 10.1007/s10517-021-05073-y
  19. Eisenach I.A., Bondarev O.I., You can V.G., Lapii G.A., Bakarev M.A. Comparative analysis of connective tissue responses to implantation of biodegradable material and polypropylene in experimental animals // Bulletin of experimental biology and medicine. – February, 2021. – Vol. 170, No. 4. – P. 505 – 510. doi: 10.1007/s10517-021-05097-4
  20. Eisenach I.A., Pichigina A.K., Lapii G.A., You can V.G. Morphogenetic aspects of the response of vaginal tissues to polypropylene implants as the basis of mesh-associated complications // Bulletin of experimental biology and medicine. – June, 2021. – Vol. 171, No. 2. – P. 265 – 269. doi: 10.1007/s10517-021-05209-0
  21. Maiborodin I., Yarin G., Marchukov S., Pichigina A., Lapii G., Krasil'nikov S., Senchukova S., Ryagusov M., William I., Bakarev M., Maiborodina V. Cell technologies in stress urinary incontinence correction // MDPI Biomedicines 2022, 10 (2), 309;