Activities

Research at the KSB laboratory is aimed at studying the modification of the functional activity of neural systems during the development of pathological conditions, in particular, psychoneurological pathology (ischemic brain lesions, affective disorders, stress-induced disorders); fMRI and EEG detection – markers and the search for methods for correcting these types of pathologies using biofeedback and virtual reality technologies.

Research methods – neurofeedback, psychophysiological monitoring, fMRI-EEG monitoring of brain activity, fMRI – biomanagement.

results – studies of central neurodynamics were conducted based on synergistic fMRI-EEG mapping of the human brain when performing cognitive operations of varying degrees of complexity in an adaptive feedback loop
A treatment and rehabilitation technology for interactive neurotherapy of cerebral infarction has been created, first clinical results obtained.
EEG patterns determined, corresponding BOLD activation of motor areas and areas, responsible for memory and attention, in healthy people and patients with consequences of stroke, based on them, neurofeedback algorithms were developed using personalized EEG profiles of patients
Strategies of behavior and psychophysiological reactions of a person were studied under simulated stress load/conditions of uncertainty using immersive virtual reality with adaptive feedback on physiological functions.
The formation of skills for self-regulation of psychophysiological functions is accompanied by activation of sensory and higher integrative structures of the cortex and is not limited to brain regions, traditionally associated with cognitive actions and operations; the success of correcting excessive stress reactions depends on comprehensive work with the cognitive and emotional spheres.

Planned results for 2024-2025 years:

• An array of neurophysiological data will be collected and summarized, describing functional relationships between cortical and subcortical motor areas (as well as with areas and systems, traditionally not related to motor), occurring after a stroke with relatively localized impairment of manual motor skills and changing during rehabilitation. Restructuring of the EEG pattern will be described, fMRI-EEG interactions in the process of rehabilitation of motor disorders are considered, taking into account laterality and a number of other clinical factors.
• Psychophysiological technology will be developed (medical technology) diagnostics, prevention and correction of stress-induced disorders using models of uncertainty and adaptive feedback, based on virtual environment simulation, initiating the development of emotional stress, controlled by physiological parameters, taking into account the neurophysiological mechanisms of regulation of autonomic indicators of stress.
  

Also in the laboratory, experimental and clinical work is being carried out to individualize the treatment and rehabilitation load of patients with cerebrovascular pathology using adaptive multiparametric biofeedback.
The essence of technology – in objectifying the current state of the patient’s cardiovascular system before, during and after biofeedback training. For this purpose, ECG signals are monitored. photoplethysmograms. and temperature – physiological parameters, responsive to change (deterioration) patient status. Objective control allows you to document the rehabilitation process in real time.
AT 2022 year, a new medical technology was created “Method for monitoring medical and rehabilitation load using monitoring of objective physiological indicators in real time”, which is implemented in the Clinic of the FRC FTM.

In recent 10 years during the research work “Study of psychophysiological patterns of formation of the skill of conscious self-regulation of involuntary functions in the biofeedback mode (on the model of training for optimal functioning for people in hazardous professions and therapeutic and rehabilitation biofeedback for patients with psychosomatic pathology and movement disorders)», “Optimal functioning in the biofeedback paradigm and the concept of “brain-computer-interface”, – the main physiological “targets” have been identified, modification of which by means and methods of biocontrol leads to sustainable changes in physiological parameters, adequate dynamics of behavioral markers, positive clinical results.
Beginning with 2017 Since 2009, studies have been conducted on central neurodynamics based on synergistic fMRI-EEG mapping of the human brain when performing cognitive operations of varying degrees of complexity in an adaptive feedback loop, where the “target” of cognitive (strong-willed, arbitrary) control is a BOLD phenomenon, separately/together with frequency ranges of electrical activity of the brain in healthy individuals.

Graduated with honors in 1984 G. Faculty of Mathematics and Mechanics, Leningrad State University, in 1989 G. defended her PhD thesis “Estimates of control parameters of random processes of a special type in biomedical problems”. AT 2006 awarded the title of associate professor in the specialty 03.00.02 "Biophysics".
From January 1999 Olga Andreevna Jafarova is the head of the laboratory of computer biocontrol systems at the Federal State Budgetary Scientific Institution “Research Institute of Molecular Biology and Biophysics”, currently – a structural subdivision of the FITs FTM.
Jafarova O.A. – professional in the field of adaptive systems (biological) feedback, conducts scientific work both in the direction of studying the psychophysiological mechanisms of conscious self-regulation, and the creation of an information environment, instrumental support for experimental work, system analysis of results, including modern methods of statistical processing of multidimensional data arrays of various structures.
Under her leadership, gaming biocontrol technology is being developed in the laboratory of computer biocontrol systems: from creating algorithms for game plots, controlled heart rate, management of software and hardware implementation projects (hardware-software complex "BOS-PULSE", RU No 29/03010300/0231-00 from 28.04.2000), before statistical analysis and psychophysiological study of experimental data. Currently, the technology is widely used for the purposes of rehabilitation and prevention of stress-related conditions., and is also actively developing for diagnostic purposes.
Work on the introduction of biofeedback technology into medical and rehabilitation practice based on the BOS-LAB hardware and software complex developed in the laboratory (RU No 29/03010300/0230-00 from 28.04.2000), with the active participation of O.A. Jafarova, led to the creation of a number of new medical technologies, including those implemented in 2018-2022 years of biofeedback techniques for neurorehabilitation of patients with motor disorders due to stroke, hush hush, TBI, implemented in the FRC FTM Clinic (link to the Neurological Department or pages with these technologies 2018-2019). In recent years, under her leadership, work has been carried out to develop methods for monitoring the adequacy of the therapeutic load at the inpatient stage of neurorehabilitation based on multiparametric biofeedback (link to medical technology 2022).
Jafarova O.A. takes an active part in developing the concept of optimal functioning, in creating a classification of self-regulation strategies in complex stressful situations. Under her leadership and with direct participation, an algorithm was created for automatic diagnostics of the effectiveness of self-regulation and assessment of stress resistance based on gaming biofeedback technology – Vira-Rally test (link to the page about gaming biofeedback). Area of ​​scientific interests – learning behavioral strategies, psychophysiological reactions of a person under simulated stress load using immersive virtual reality, psychophysiological training for people in hazardous professions (link to the page about the virtual reality simulator). The result of her work was the introduction of these methods in various organizations, engaged in training specialists in extreme professions and individuals, involved in leadership activities (2014-2019 years).
All research and development, which is conducted by Jafarova O.A., have important practical significance for creating new methods and means of rehabilitating patients and maintaining the health of the working population of Russia.
Laboratory team for computer biocontrol systems, led by Olga Andreevna, is a team of specialists in various fields, which allows them to solve fundamental, applied, technical tasks in a comprehensive manner, maintain the quality of research at the Novosibirsk Scientific School of Biofeedback (head and founder of the school – Academician of the Russian Academy of Sciences M.B.. Stark, link to Stark's page) at the global level.
Jafarova O.A. – author more 120 scientific works and 9 computer programs, protected under her leadership 2 PhD dissertations.

Laboratory staff

1. Bazanova Olga Mikhailovna, Doctor of Biological Sciences, Chief Researcher, bazanova_olgamih@mail.ru
2. Mazhirina Ksenia Gennadievna, Candidate of Psychological Sciences, Senior Researcher, ksyh@mail.ru
3. Bezmaternykh Dmitry Dmitrievich, Researcher,dmitrii.93@ya.ru
4. Danylenko Elena Nikolaevna, Researcher, elena.danilenko2011@yandex.ru
5. Kozlova Lyudmila Igorevna, Researcher,lyudmilakozlova@yandex.ru
6. Tsirkin Georgy Maksimovich, Researcher, gtsirkin@gmail.com
7. Tishakin Dmitry Igorevich, research laboratory assistant, dmitro_tish@mail.ru
8. Melnikov Mikhail Evgenievich, candidate of biological sciences, Leading Researcher, mikhail-melnikov@mail.ru
9. Shubina Olga Sergeevna, Candidate of Medical Sciences, Leading Researcher, olga__22@mail.ru
10. Zubkov Alexander Alekseevich, software engineer, alex.phenik@yandex.ru
11. Tarasov Evgeniy Alexandrovich, Lead Software Engineer, eugen_tarasov@ngs.ru
12. Lazareva Olga Yurievna, R&D specialist, olazar@mail.ru
13. Petryk Svetlana Vladimirovna, R&D specialist, svpetrik@frcftm.ru, svpetrik@bk.ru, 8(383) 335-97-56