Direction of work – study of molecular and cellular mechanisms of socially significant chronic diseases in their modeling. Research Methods - Animal Experiments, morphological, functional, immunohistochemical, molecular biological.

Mayborodin Igor Valentinovich graduated from 1985 G. Novosibirsk Medical Institute, in 1992 G. defended his thesis on the topic "Lymphoid organs under the influence of interferon", in 1998 G. – doctoral dissertation on the topic “Morphofunctional substantiation of the use of sorption-lymphatic drainage of tissues in acute and chronic inflammation (experimental clinical study)», in 2000 G. - Professor of Human Anatomy.

The main direction of scientific research is the study of the structural reorganization of the lymph nodes and microcirculatory disorders in inflammatory and neoplastic processes., as well as in the conditions of application of cellular technologies.

I.V. Mayborodin for the last 10 years, studies have been conducted to assess the regenerative potential of multipotent stem cells (MSC). The reorganization of the dense fibrous connective tissue of the scar was established as a result of the use of MSCs, which are involved in angiogenesis. For example, with cicatricial obstruction of the uterine horns, the introduction of MSCs will lead to a faster restoration of reproductive function. However, in some cases, MSCs enhance sclerosis and may themselves cause the development of connective tissue.. After injection into a bone defect, MSCs accelerate regeneration, but not only bones, but also in the red bone marrow. At the same time, differentiation of MSCs into bone tissue cells was not found., osteogenesis is angiogenic, it is possible, that due to the participation of MSCs in angiogenesis. The conducted studies confirm the need for a careful choice of scaffold for MSCs.. Installed, that MSCs can be used to accelerate the development of granulation tissue vessels, since MSCs themselves can directly participate in angiogenesis, differentiating into vascular cells; after surgical operations, this can contribute to a faster cleansing of the wound from detritus and an earlier start of repair processes.

Shown, that for the correction of venous thrombosis or the elimination of a local obstruction to venous outflow, even in case of damage to the main vessel, MSC use is inefficient, since the restoration of the patency of the vascular bed in these cases occurs either due to thrombolysis or due to the reorganization of collateral vessels without the participation of the introduced MSCs.

In a series of studies to evaluate the effectiveness of cellular technologies for optimizing regenerative processes during implantation of various materials, it was shown, that MSCs adsorbed on implants accelerate the lysis of biodegradable substances due to the formation of a large number of blood vessels from MSCs, which facilitates the infiltration of implants by phagocytes, fibroblasts and other cells. In the case of the introduction of non-degradable materials, MSCs do not affect the processes of capsule formation, but increase the number of vessels around it and, due to the suppression of inflammation, reduce the degree of sclerosis of surrounding tissues. Despite literature data, no differentiation of injected MSCs into highly specialized cells of organ structures was found. A special conclusion from the conducted studies is the possibility of spreading MSCs introduced locally into tissues into the lungs and further throughout the body.. As a side effect of MSCs, the progression of an ascending urinary tract infection was registered - in the kidneys of experimental animals after the injection of MSCs into the inguinal region., What, more likely, due to the immunomodulatory effect of cell therapy.

Due to side effects, incomplete predictability of results and the impossibility of standardizing MSCs, even from the same source, a few years ago, a gradual transfer of the center of research from MSCs to their extracellular microvesicles began (EMW). Shown, that the use of EMW has great potential for reparative medicine and opens up new avenues for medical research. I.V. Maiborodin established, what to use in future EMW clinical trials, secreted by various MSCs, should be standardized, stored under strictly defined conditions, free of xenogeneic and other source-related substances.

Author over 300 scientific papers, including 3 copyright certificate for invention.

Under guidance and consultation protected 13 doctoral and 44 PhD theses.

I.V. Mayborodin - member of the council for the defense of doctoral and master's theses 24.1.242.03 in FGBNU "FITS FTM" (specialty - "pathological anatomy").

– member of the council for the defense of doctoral and candidate dissertations of the ICBFM.03.01 at the Institute of Chemical Biology and Fundamental Medicine” SB RAS (specialty - "biochemistry").

– member of the council for the defense of doctoral and master's theses 21.2.013.02 at FGBOU HE “Krasnoyarsk State Medical University named after Professor V.F.. Voyno-Yasenetsky” Ministry of Health of the Russian Federation (specialty - "Human Anatomy").

Major Publications:

1. Sukhikh G.T., Pekarev O.G., Maiborodin I.V., Silachev D.N., Shevtsova Y.A., Goruunov K.V., Onoprienko N.V., Maiborodina V.I., Galenok R.V., Novikov A.V., Pekareva E.O. Preservation of mesenchymal stem cell-derived extracellular vesicles after abdominal delivery in the experiment. Bull Exp Biol Med. 2020;169(1):122-129. doi: 10.1007/s10517-020-04838-1.
2. Maiborodin I.V., Maslov R.V., Mikheeva T.V., Marchukov S.V., Maiborodina V.I., Shevela A.A. Opportunity for elimination of injected multipotent stromal cells via lungs. Cellular Therapy and Transplantation (CTT). 2020;9(1):67-73. doi: 10.18620/ctt-1866-8836-2020-9-1-67-73.
3. Maiborodin I., Lushnikova E., Klinnikova M., Klochkova S. Some Special Aspects of Liver Repair after Resection and Administration of Multipotent Stromal Cells in Experiment. Life (Basel). 2021;11(1):66 doi: 10.3390/life11010066. Q2
4. Maiborodin I., Shevela A., Toder M., Marchukov S., Tursunova N., Klinnikova M., Maiborodina V., Lushnikova E., Shevela A. Multipotent Stromal Cell Extracellular Vesicle Distribution in Distant Organs after Introduction into a Bone Tissue Defect of a Limb. Life (Basel). 2021;11(4):306. doi: 10.3390/life11040306. Q2
5. Pekarev AND, Pekareva EO, Mayborodin IV, Silachev DN, Baranov II, Pozdnyakov IM, Bushueva NS, Novikov AM, Sukhikh GT. The potential of extracellular microvesicles of mesenchymal stromal cells in obstetrics. J Mater Fetal Neonatal Med. 2021:1-3. doi: 10.1080/14767058.2021.1951213. PMID: 34344283.
6. Maiborodin I., Shevela A., Matveeva V., Morozov V., Toder M., Krasil'nikov S., Koryakina A., Shevela A., Yanushevich O. First Experimental Study of the Influence of Extracellular Vesicles Derived from Multipotent Stromal Cells on Osseointegration of Dental Implants. Int. J. Mol. Sci. 2021;22(16):8774. doi: 10.3390/ijms22168774. Q1
7. Maiborodin I., Klinnikova M., Kuzkin S., Maiborodina V., Krasil'nikov S., Pichigina A., Lushnikova E. Morphology of the Myocardium after Experimental Bone Tissue Trauma and the Use of Extracellular Vesicles Derived from Mesenchymal Multipotent Stromal Cells. J. Pers. With. 2021, 11(11), 1206. doi: 10.3390/jpm11111206. Q1
8. Maiborodin I, Yarin G, Marchukov S, Pichigina A, Lapii G, Krasil'nikov S, Senchukova S, Ryaguzov M, William I, Bakarev M., Maiborodina V. Cell Technologies in the Stress Urinary Incontinence Correction. Biomedicines. 2022;10(2):309. doi: 10.3390/biomedicines10020309. PMID: 35203518. Q1