Direction of work – study of molecular and cellular mechanisms of socially significant chronic diseases in their modeling. Research methods - morphological, functional, immunohistochemical, molecular biological.

Graduated in 1989 G. Novosibirsk State Agrarian University, in 1997 G. defended her thesis on the topic "Structural organization of the adrenal cortex of rats under hypoxic effects and their correction with nerobolil", in 2009 G. – doctoral dissertation on the topic “Ultrastructural reorganization of the adrenal cortex under extreme exposure (general hypoxia, hyperthermia and genetically determined metabolic disorders)».

The main direction of scientific research is the study of the structural mechanisms of compensatory-adaptive reactions under the influence of extreme environmental factors and age-related features of regeneration and remodeling of the heart..

E.V. Koldysheva carried out original morphological studies of the adrenal glands during the reproduction of extreme environmental impacts - the influence of hypobaric hypoxia, general overheating of the body, natural and premature (genetically determined metabolic disorders) aging. Remodeling of the adrenal cortex under the action of extreme factors has been shown, manifested in: transient atrophy with acute exposure and hypertorophia with repeated stressful exposure. Installed, that stress-induced remodeling of the adrenal cortex is determined by the development of a general adaptation syndrome, an increase in regenerative-plastic insufficiency and restoration of intracellular regeneration processes.

Author over 70 scientific articles, 1 monographs.

E.V. Koldysheva - member of the council for the defense of doctoral and master's theses 24.1.242.03 and 24.1.242.01 in FGBNU "FITS FTM" (specialty - "cell biology".

Major Publications:

1. Korolenko T.A., Ovsyukova M.V., Bgatova N.P., Ivanov I.D., Makarova S.I., Vavilin V.A., Popov A.V., Yuzhik E.I., Koldysheva E.V., Korolenko E.T., Zavjalov E.L., Amstislavskaya T.G. Tregalose activates hepatic and myocardial autophagy and demonstrates anti-inftammatory effects in Db/db diabetic mice // Life. 2022, Vol. 12, 442. https://doi.org/10.3390/life12030442
2. Kuzkin S.A., Maiborodin I.V., Koldysheva E.V., Klinnikova M.G., Maiborodina V.I. Pathomorphology of the myocardium in case of distant bone tissue damage and the use of exosomes of multipotent stromal cells // Modern problems of science and education. – 2021. – № 5; DOI: 10.17513/spno.31136
3. Mzhelskaya M.M., Klinnikova M.G., Koldysheva E.V., Lushnikova E.L. Expression of Flk-1 and mRNA of cyclin D2 in the myocardium in doxorubicin-induced cardiomyopathy and administration of betulonic acid amide // Bull. expert. biol. – 2017. - T. 163, № 6. – S. 778 – 783.
4. Lushnikova E.L., Semenov D.E., Nikityuk D.B., Koldysheva E.V., Klinnikova M.G.. Intracellular reorganization of cardiomyocytes in dyslipidemic cardiomyopathies // Bull. expert. biol. – 2017. - T. 164, № 10. – S. 512 – 518.
5. Koldysheva E.V., Klinnikova M.G., Nikityuk D.B., Ivleva E.K., Listvyagova N.A., Lushnikova E.L. The role of matrix metalloproteinase-2 in the development of cyclophosphamide-induced cardiomyopathy // Bull. expert. biol. – 2017. - T. 164, № 10. – S. 484 – 489.
6. Lushnikova E.L., Klinnikova M.G., Nikityuk D.B., Koldysheva E.V., Yuzhik E.I., Mzhelskaya M.M.. Structural basis of myocardial remodeling under the action of cyclophosphamide and corrector K⁺, Mg²⁺-ion exchange in cardiomyocytes // Modern problems of science and education. – 2016. – № 5; URL: http://www.science-education.ru/article/view?id=25208
7. Koldysheva E.V., Klinnikova M.G., Ivleva E.K., Listvyagova N.A., Lushnikova E.L. Expression of KDR/Flk-1 (VEGFR2) in the myocardium in modeling anthracycline cardiomyopathy // Modern problems of science and education. – 2016. – № 6. URL: http://www.science-education.ru/article/view?id=25577
8. Lushnikova E.L., Nikityuk D.B., Klinnikova M.G., Koldysheva E.V., Mzhelskaya M.M.. Expression of metalloproteinase-2 in the myocardium in the modeling of anthracycline cardiomyopathy // Morphology. – 2016. - T. 150, № 6. – S. 29 – 34.
9. Klinnikova M.G., Lushnikova E.L., Koldysheva E.V., Tolstikova T.G., Sorokina I.V., Yuzhik E.I., Mzhelskaya M.M. Cardiotoxic and Dyslipidemic Effects of Doxorubicin and Betulinic Acid Amide // Bull. Exper. Biol. With. – 2016 (December). – Vol. 162 (2). – P. 277 – 282. DOI 10.1007/s10517-016-3594-9 http://link.springer.com/article/10.1007/s10517-016-3594-9