Activities – Study of the influence of non-infectious and infectious risk factors on the development of comorbid pathology in ontogeny.

Research methods – clinical, functional, biochemical

Graduated in 1985 G. Novosibirsk State Medical Institute, in 1991 G. defended his thesis on the topic "Evaluation of the course and prognosis of patients with hypertrophic cardiomyopathy depending on the presence of circulatory failure", in 2002 G. – doctoral dissertation on the topic “Assessment of the development and mechanisms of progression of arterial hypertension in the newcomer population in the North”.

The main direction of scientific research is the study of the influence of non-infectious and infectious risk factors on the development of comorbid pathology in ontogenesis and the features of the formation of clinical manifestations of comorbid conditions in residents of Siberia and the North. Development of new principles for the organization of prevention and treatment as the basis of personalized medicine

Yu.A. Nikolaev studied the general patterns and some regional features of the formation of comorbid pathology in patients, inhabitants of Siberia and the North and identified its pathogenetic links. A significant increase in the indicator of transsystemic polymorbidity was revealed in the period from 2003 G. on 2020 Mr., as among the inhabitants of the NSO, and among the inhabitants of the Republic of Sakha (Yakutia) in 1,4 times, with defeat from 3-4 systems in 2003-2008 years. to 4-5 systems in 2015-2020 years. Increase in polymorbidity in patients, residents of the NSO and the Republic of Sakha (Yakutia), was conditioned, Firstly, an increase in the incidence of diseases of the nervous system, endocrine system and metabolic disorders, circulatory systems, respiratory system (predominantly, residents of NSO, on 19%), infectious diseases (predominantly among the inhabitants of Yakutia, on 26%), mental and behavioral disorders (on 36,6% and 32,9%, respectively). Regional features of polymorbidity were manifested by its large values ​​and a higher incidence of diseases in the main classes of ICD. -10 (respiratory diseases, digestion, musculoskeletal system and connective tissue, genitourinary system, circulatory systems, neoplasms) in the structure of polymorbidity in patients, living in the Republic of Sakha (Yakutia), compared to patients, living in the NSO. These differences were made up of higher rates of polymorbidity in men of adolescence and the second mature age periods and in women of all age periods., except for youth. Gender features of polymorbidity were manifested by higher rates in women, among the inhabitants of the NSO – in the second mature and elderly age periods; among the inhabitants of Yakutia – in all age periods, except for youth. Age-related features were manifested by an increase in polymorbidity with increasing age, as well as changes in its structure in different age periods with a predominance of diseases of the digestive system in the youthful age period, diseases of the digestive organs and the musculoskeletal system in the first and second mature age periods and diseases of the circulatory system in the elderly and senile age periods.

New knowledge gained about, that in patients with ischemic heart disease (CHD) C-reactive protein (SRB) correlated with the severity of disorders of carbohydrate, lipid metabolism, hemostasis system and is an indicator, reflecting the degree of polymorbidity. With an increase in CRP values, a statistically significant decrease in the concentration of high-density lipoprotein cholesterol in the blood serum was found., increase in the atherogenic index, glucose levels, uric acid, fibrinogen and soluble fibrin-monomer complexes. The role of CRP as an indicator of comorbidity involving chronic systemic inflammation has been established., violation of metabolic processes and hemostasis system. The relationship of hyperuricemia (Gu) with changes in lipid profile and carbohydrate metabolism, visceral obesity, increased blood pressure and its association with an increase in the degree of polymorbidity in patients with coronary heart disease (CHD). Shown, that an elevated serum level of uric acid can serve as one of the markers of polymorbidity in patients with coronary artery disease.  Installed, that in patients with verified atherosclerosis of the brachiocephalic arteries, gene expression is reduced, involved in the formation of antioxidant protection (GAPDH, HMO1, NQO1, NRF2) compared with individuals without atherosclerotic lesions. Interrelations between expressiveness of expression of genes GSTP1, HMOX1, NQO1, NRF2 and biochemical parameters of the lipid spectrum and the degree of stenosis of the carotid arteries. Based, acquired fundamental knowledge, new medical treatment technologies have been developed, rehabilitation, diagnostics and prevention

Author over 350 scientific papers. 16 new medical technologies. Led by reserved 5 PhD and counseling 2 doctoral dissertations. Yu.A. Nikolaev is a member of the Dissertation Council at the FRC FTM. Member of the Academic Council at FIC FTM, Chairman of the local Bioethical Committee at the FRC FTM.

Publications

https://www.elibrary.ru/author_items.asp?authorid=192824

Laboratory staff

1. Polyakov Vladimir Yakovlevich
   Leading Researcher Doctor of Medical Sciences
   vpolyakov15@mail.ru
2. Sevostyanova Evgeniya Viktorovna
   Senior Research Fellow Candidate of Biological Sciences
   luck.nsk@rambler.ru,
3. Mitrofanov Igor Mikhailovich
   Leading Researcher Doctor of Medical Sciences
   mim@mail.ru
4. Pospelova Tatyana Ivanovna
   Leading Researcher Doctor of Medical Sciences, professor
   post_gem@mail.ru
5. Volkova Tatyana Vladimirovna
   Research laboratory assistant