Activities – study of the role of glycosylated macromolecules (proteoglycan, glycosaminoglycan) in the occurrence and progression of malignant tumors.

Grigorieva Elvira Vitalievna

Head of laboratory, Doctor of Biological Sciences

elvira.grigorieva@niimbb.ru

+7(383) 274-9557

The main areas of research E.V.. Grigorieva are focused in the field of molecular oncology and are devoted to the study of the role of glycosylated macromolecules and the tumor microenvironment in the molecular mechanisms of the development and progression of malignant tumors.. Considerable influence is also being given to the study of the potential of glycosylated extracellular macromolecules as prognostic markers and to the study of the molecular mechanisms of action of chemoradiotherapy and its negative side effects in the treatment of glioblastoma.

E.V.Grigorieva is the author of more 100 scientific works, published in the domestic press and in leading international journals. Under the guidance of E.V. Grigoryeva, five dissertations were completed. Project manager, funded by the Russian Foundation for Basic Research, Russian Science Foundation, Swedish Institute (Swedish Institute, Sweden). Foreign internships – in Italy, USA, Sweden, including those supported by FEBS personal grants (Federation of European Biochemical Societies) and UICC (European Cancer Union). He is an expert of the Russian Science Foundation, Innovation Assistance Fund and UICC (ICRETT programs

Member of the editorial boards of the journals "Frontiers in Oncology" (Section Radiation Oncology – Review Editor, Molecular and Cellular Oncology section – Guest Associate Editor), “Advances in Molecular Oncology”;

reviewer for Nature Communications journals, Blood, PLOS Genetics, PLOS One, Scientific Reports, Oncotarget, International Journal of Molecular Sciences, Cells, International Journal of Cancer, Epigenetics, Matrix Biology, Cell Adhesion and Migration, Cancer Microenvironment, BBA General Subjects, Tumor Biology, Oncology Reports, Frontiers in Endocrinology, Frontiers in Oncology и др.;

member of the Federation of European Biochemical Societies (FEBS), European Cancer Society (UICC Fellow), Russian Society of Clinical Oncology (RUSSCO), European Society of Clinical Oncology (ALMOST);

RSF expert, European Cancer Society (UICC) for ICRETT and Yamagiwa-Yoshida grant programs, Fund for Assistance to the Development of Small Forms of Enterprises in the Scientific and Technical Sphere (competition “SMART ASS”).

Currently, the main direction of work is related to the study of the role of glycosylated macromolecules. (proteoglycan, glycosaminoglycan) in the development of such the most aggressive brain tumor as glioblastoma. Our goal is to study the molecular mechanisms of the development of glioblastoma and the side effects of adjuvant chemoradiotherapy., used in her treatment.

Main goals:

  • Identification of molecular markers of negative prognosis of glioblastoma.
  • Study of the functional role of glycosylated macromolecules in the development of disease recurrence.
  • Identification of new molecular mechanisms for the development of side effects of postoperative chemoradiotherapy (x-ray exposure, temozolomide chemotherapy).
  • Studying the effect of glucocorticoid drugs (which are used as an accompanying therapy to prevent cerebral edema) on the intercellular substance of normal brain tissue and its role in the development of disease recurrence, optimization of the use of glucocorticoids and the search for their less toxic analogues.

Solving these problems will allow developing strategies for optimizing postoperative treatment of glioblastoma., which will reduce its negative side effects, improving the effectiveness of treatment and quality of life of patients with this disease. The work of the laboratory is consistently supported by RFBR grants, Russian Science Foundation and administration of the Novosibirsk region.

Publications

  1. Strokotova A.V., Grigorieva E.V. Glucocorticoid Effects on Proteoglycans and Glycosaminoglycans. Int J Mol Sci. 2022, Dec 10;23(24):15678
  2. Politko MO, Tsidulko AY, Pashkovskaya OA, Kuper KE, Suhovskih AV, Kazanskaya GM, Klyushova LS, Sokolov DK, Volkov AM, Steps EE, Zheravi AA, Aidagulova SV, Grigorieva E.V. Multiple Irradiation Affects Cellular and Extracellular Components of the Mouse Brain Tissue and Adhesion and Proliferation of Glioblastoma Cells in Experimental System In Vivo. Int J Mol Sci. 2021, Dec 12;22(24):13350
  3. Tsidulko A.Y., Shevelev O.B., Khotskina A.S., Kolpakova M.A., Suhovskih A.V., Kazanskaya G.M., Volkov A.M., Aidagulova S.V., Zavjalov E.L., Pankova T.M., Kazanskaya G.M., Aidagulova S.V., Grigorieva E.V. Chemotherapy-induced degradation of glycosylated components of brain extracellular matrix promotes glioblastoma relapse development in animal model. Frontiers in Oncology 2021, 29 June
  4. Grigorieva E.V. Radiation effects on brain extracellular matrix. Frontiers in Oncology 2020, 0:576701
  5. Politko M.O., Prokaeva A.I., Pashkovskaya O.A., Kuper K.E., Zheravin A.A., Kliver E.E., Tsidulko A.Y., Suhovskih A.V., Aidagulova S.V., Grigorieva E.V. Single X-ray irradiation modulates proteoglycan expression in brain tissue: investigation using mouse model. Mol.Biol.Rep. 2020, V. 47, N7, P. 5657-5663
  6. Politko M.O., Prokaeva A.I., Pashkovskaya O.A., Zheravin A.A., Kazanskaya G.M., Volkov A.M., Kolpakova M.A., Tsidulko A.Y., Suhovskih A.V., Aidagulova S.V., Grigorieva E.V. Mouse model to study irradiation effects on brain extracellular matrix in vivo. Int.J.Eng.Sci.Res.Tech. 2020, V. 9, N5, R. 213-221
  7. Suhovskih A.V., Kazanskaya G.M., Volkov A.M., Tsidulko A.Y., Aidagulova S.V., Grigorieva E.V. Chemoradiotherapy Increases Intratumor Heterogeneity of HPSE Expression in the Relapsed Glioblastoma Tumors. Int J Mol Sci. 2020, V.21, 4:1301
  8. Tsidulko A.Y., Kazanskaya G.M., Volkov A.M., Suhovskih A.V., Kiselev R.S., Kobozev V.V., Gaytan A.S., Krivoshapkin A.L., Aidagulova S.V., Grigorieva E.V. Chondroitin sulfate content and decorin expression in glioblastoma are associated with proliferative activity of glioma cells and disease prognosis. Cell Tissue Res. 2020 V. 379, N1, R. 147-155
  9. Suhovskih A.V., Kazanskaya G.M., Volkov A.M., Tsidulko A.Y., Aidagulova S.V., Grigorieva E.V. Suitability of RNALater solution as a tissue-preserving reagent for immunohistochemical analysis. Histochem Cell Biol. 2019. V. 152. N. 3. R. 239–247
  10. Tsidulko A.Y., Bezier C., de La Bourdonnaye G., Suhovskih A.V., Pankova T.M., Kazanskaya G.M., Aidagulova S.V., Grigorieva E.V. Conventional Anti-glioblastoma Chemotherapy Affects Proteoglycan Composition of Brain Extracellular Matrix in Rat Experimental Model in vivo. Front Pharmacol. 2018. V. 9. P. 1104-1117
  11. Kazanskaya G.M., Tsidulko A.Y., Volkov A.M., Kiselev R.S., Suhovskih A.V., Kobozev V.V., Gaytan A.S., Aidagulova S.V., Krivoshapkin A.L., Grigorieva E.V. Heparan sulfate accumulation and perlecan/HSPG2 up-regulation in tumour tissue predict low relapse-free survival for patients with glioblastoma. Histochem Cell Biol. 2018. V. 149(3). P. 235-244
  12. Sukhovskikh A.V., Grigorieva E.V. Proteoglycans in normal physiology and carcinogenesis. Advances in molecular oncology. 2018. T. 5. №1. p. 8-25

Laboratory staff

  1. Grigorieva Elvira Vitalievna
    rt +7(383) 274 9557
  2. Aidagulova Svetlana Vladimirovna
    rt +7(383) 274 9559
  3. Kazanskaya Galina Mikhailovna
    rt +7(383) 274 9559
  4. Strokotova Anastasia Vladimirovna
    rt +7(383) 274 9559
    avstrokotova@frcftm.ru
  5. Politko Maxim Olegovich
    rt +7(383) 274 9558
  6. Sokolov Dmitry Konstantinovich
    rt +7(383) 274 9558
  7. Aladiev Stanislav Dmitrievich
    rt +7(383) 274 9558
    s.aladev@alumni.nsu.ru
  8. Aksenova Ludmila Vasilievna
    rt +7(383) 274 9558
  9. Kotyusheva Tatyana Innokentievna
    rt +7(383) 274 9558
  10. Sergeeva Elena Yurievna
  11. Pervunin Daniil Igorevich
    rt +7(383) 274 9558
    d.pervunin@g.nsu.ru
  12. Kolpakova Maria Alexandrovna
  13. Nikitina Sofia Andreevna