The main activities of the Research Institute of Virology:

  1. Conducting basic scientific research to identify newly emerging and returning viral infections, study of molecular biological properties of identified pathogens. Assessment of the impact of identified pathogens on socially significant human somatic diseases.
  2. Development of new principles and diagnostic technologies, treatment of newly emerging and recurring diseases of viral etiology.
  3. Expansion and development of international scientific relations with foreign research organizations and universities in order to exchange experience, reducing the time to obtain international-level results in the declared field of knowledge and research, search for interested partners for the implementation of the developed tools and technologies, increasing the prestige of domestic science.
  4. Training of highly qualified scientific and medical personnel in the field and in leading domestic and international centers on the stated scientific issues

Main scientific directions:

  1. Risk Based Monitoring of Zoonoses, including:
  • analysis of circulating zoonoses dangerous to humans and farm animals in little-studied reservoirs (birds, marine and aquatic mammals, domestic cats and dogs, the bats, imported monkeys) Asian part of Russia, assessment of the risks of their transmission to humans and farm animals.
  • assessment and analysis of the anthropogenic impact on the circulation of zoonotic pathogens in poorly studied reservoirs in areas with different anthropogenic and technogenic pressures.
  • development of a system for risk-based monitoring of zoonoses in the Asian part of Russia in little-studied reservoirs.
  1. Optimization of ARVI diagnostics and control, including:
  • study of the etiological structure of acute respiratory viral infections in the framework of cooperation with hospitals in. Novosibirsk and Novosibirsk region, as well as highlighting, antigenic analysis and study of the biological properties of human influenza virus strains, circulating in Western Siberia.
  • assessment of toxicities in vitro (cell culture) it's alive (laboratory animals) vaccine, as well as new connections, promising for use in medical practice.
  • study of antiviral activity of compounds and preparations in vitro (cell culture) it's alive (laboratory animals) regarding the influenza virus, including new strains of avian influenza virus, potentially dangerous to humans and mammals.
  • study of the pathogenesis of influenza infection in laboratory animals, caused by different strains of the influenza virus (including highly pathogenic avian influenza virus), for the purpose of assessing pathogenicity for mammals; risk assessment, epidemic and pandemic potential for humans.
  1. Ecology of viruses, including:
  • molecular virology and molecular epidemiology of influenza viruses (Avian Influenza viruses), ecology of influenza viruses and their hosts, interspecies transmission mechanisms, study of highly pathogenic avian influenza virus (HPAI) and its pathogenicity using animal models;
  • antigenic variability and evolution of the influenza virus.
  • molecular epidemiology and virology of avian paramyxoviruses (Avian Paramyxoviruses).
  1. Molecular genetic research, including:
  • study of the primary structure primarily of the genomes of influenza viruses, circulating as in the human population, as well as among animals, as well as the study of the genomes of other viral pathogens with hemagglutinating activity (paramyxoviruses of various types, including. virus disease to Newcastle), circulating in the bird population in the Asian part of the Russian Federation.
  • analysis of amino acid substitutions, as well as patterns of their accumulation and fixation, detection of changes in antigenic determinants and functional regions of proteins of viral pathogens.
  • study of the genetic basis of the pathogenesis of influenza.
  • detection of viral pathogens in biological samples by molecular biological methods. Typing and subtyping of influenza viruses, circulating among animals.
  • development and testing of methods for rapid identification of influenza viruses types A and B.
  • study of the genetic diversity of viral pathogens.
  1. Experimental oncology, including:
  • study of the effectiveness of oncolytic viruses as antitumor agents, which have the ability to selectively kill malignant cells, without affecting healthy non-transformed cells.
  • search for oncotherapeutic agents against malignant neoplasms and development of methods for their use.
  • study of the effectiveness of direct oncolysis of tumor cells and the immunomodulatory activity of new anticancer drugs based on natural strains of the Newcastle disease virus using models and methods of experimental oncology in vitro and in vivo .
  • study of the mechanisms of the antitumor action of oncolytic viruses to identify the selectivity of the antitumor potential in relation to different types of tumors, as well as predicting the course of the tumor process, selection of optimal therapeutic doses and individualization of therapy.

Main achievements of the Research Institute of Virology:

Among the world achievements of the Research Institute of Virology is the development of criteria for assessing the environmental and social significance of new and re-emerging viral anthropozoonotic infections; for the first time for the Asian part of the Russian Federation, methods have been developed for conducting phylogeographic studies of synanthropic birds in Central Asia; a number of developments on the diagnosis of RNA-containing viruses.

The biological properties and genetic features of the obtained strains of H5N1 and H1N1pdm09 avian influenza viruses were studied., the created collection of highly pathogenic strains was deposited in the state collections of the FBUN SSC WB Vector (Novosibirsk) and Research Institute of Influenza (Saint Petersburg). Collection of Newcastle disease virus strains created, possessing oncolytic properties and promising for the creation of anticancer drugs. The strains are deposited in the state collections of the FBUN SRC WB Vector (Novosibirsk), Research Institute of Virology named after. Ivanovsky (Moscow).