Genetic Engineering Laboratory

Beklemishev Anatoly Borisovich

Head of Laboratory - Chief Researcher. Doctor of Biological Sciences, professor

abbeklem-46@yandex.ru

+7 (383) 274 94 26

Graduated in 1969 G. Kazakh State University named after. CM. Kirov, in 1974 G. defended his thesis on the topic "Comparative study of the physicochemical properties of ribosomes and ribosomal subparticles of higher plants and mammals" in the specialty "biochemistry". The area of ​​his scientific interests during this period of time was the study of the regulation of eukaryotic protein biosynthesis at the translation level. He was the first to demonstrate the possibility of forming functionally active hybrid ribosomes from ribosomal subparticles of higher plants and mammals.
S 1978 on 1986 Mr. Mr. worked at the All-Russian Research Institute of Molecular Biology (now SSC VB "Vector") where he formed a circle of scientific interests, determined all his subsequent scientific activity. Under his leadership, the institute began work on the creation of a new generation of vaccines.. The main scientific works during this period are devoted to the structural and functional study of the genomes of pathogenic viruses and the development of molecular vaccines and diagnostic products using modern methods of molecular biology and genetic engineering.. Research into this
direction were carried out by Beklemishev A.B. and in subsequent years. AT 2004 G. defended his doctoral dissertation on the topic "Using the methods of molecular biology and genetic engineering for the design of vaccine and diagnostic products" in the specialties "biochemistry" and "molecular biology". AT 2010 year he was awarded the title of professor in the specialty “molecular biology”. During his work at the Research Institute of Biochemistry of the Federal Research Center for Physics and Technology SB RAS, systems of tuberculosis pathogens were developed in the laboratory he led, Lyme borreliosis and hepatitis B and C, based on PCR and RT-PCR methods. Antigen based, obtained by genetic engineering methods, immunoenzyme systems for the diagnosis of tuberculosis and Lyme borreliosis were created, and using recombinant protein, fatty acid binder, together with
Biotest LLC immunochromatographic system for early detection of myocardial infarction. Original whole-cell biosensors were designed to assess the toxic and mutagenic effects of the studied compounds, which can be used in food, pharmaceutical and chemical industry.
Latest 7 For years, the main direction of the laboratory’s research has been obtaining the expression of recombinant cytokines in the yeast system, human colony-stimulating factors and enzymes of various natures for the creation on their basis of immunobiological drugs for restorative medicine.

A.B. Beklemishev is the author 132 articles, published in domestic and foreign journals, including: three monographs and 19 inventions. Under his leadership, executed and protected 9 PhD theses. Member of the dissertation council 24.1.242.02 for the defense of doctoral and master's theses at the Federal State Budgetary Institution "FRC FTM" (speciality - 1.5.4. "biochemistry", medical and biological sciences).